J&J ends JNJ-5939 trial early in atopic dermatitis after missing efficacy mark

J&J ends JNJ-5939 trial early in atopic dermatitis after missing efficacy mark

Johnson & Johnson (J&J) announced that its investigational candidate JNJ-95475939 (JNJ-5939) failed to meet prespecified efficacy criteria in the DUPLEX-AD Phase 2b trial for moderate to severe atopic dermatitis. Following an interim analysis, the study was terminated early. Despite showing a favorable tolerability profile, the molecule did not demonstrate sufficient clinical efficacy to warrant continuation. […]

Can Alphyn’s multi-target strategy disrupt dermatology? Why Zabalafin’s $25m backing matters

Can Alphyn’s multi-target strategy disrupt dermatology? Why Zabalafin’s $25m backing matters

Alphyn Biologics has secured $25 million in a twice-oversubscribed Series B financing round to support its clinical pipeline for dermatologic conditions. The funding will enable the company to advance a global Phase 2b trial of its lead asset, Zabalafin Hydrogel, for atopic dermatitis, while also launching a second Phase 2 program for molluscum contagiosum virus. […]