Is BRCA the new EGFR? Why germline mutations are reshaping prostate cancer treatment strategies

Is BRCA the new EGFR? Why germline mutations are reshaping prostate cancer treatment strategies

The recent FDA approval of Rubraca (rucaparib) for pre-chemotherapy use in BRCA-mutated metastatic castration-resistant prostate cancer marks a strategic inflection for the field. This expanded indication, driven by head-to-head superiority over docetaxel in the TRITON3 Phase 3 trial, positions BRCA mutations as the first molecular biomarker in prostate cancer to carry actionable, label-defining weight in […]

Beyond ovarian and breast cancer: Are PARP inhibitors finally proving their worth in urologic oncology?

Beyond ovarian and breast cancer: Are PARP inhibitors finally proving their worth in urologic oncology?

The class of poly (ADP-ribose) polymerase inhibitors, once celebrated as a breakthrough in ovarian and breast cancer, has endured a reputation decline following safety concerns and regulatory rollbacks. But recent data suggest that prostate cancer, specifically metastatic castration-resistant prostate cancer with BRCA mutations, may offer PARP inhibitors a new lease on life. The December 2025 […]