Obuprazine met the primary endpoint across three dose groups in a 363-patient Phase 2b schizophrenia study, with the strongest dose producing a 16.7-point placebo-adjusted PANSS improvement. Early symptom responses and low discontinuation rates support further development, but longer-term safety and comparative efficacy remain unproven.
GSK’s licensed B7-H3 antibody-drug conjugate Ris-Rez delivered median survival of 18.5 months versus 10.3 months with topotecan in a Chinese Phase 3 study, strengthening the company’s case for global development.
Hansoh Pharmaceutical Group Co., Ltd. has reported that risvutatug rezetecan, also known as Ris-Rez or HS-20093, significantly improved overall survival in the pivotal Phase 3 ARTEMIS-008 trial involving Chinese patients with advanced or relapsed small-cell lung cancer following platinum-based treatment. The B7-H3-directed antibody-drug conjugate was compared with topotecan and also produced a consistent benefit in