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PAPILLON

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Johnson & Johnson’s PAPILLON trial reported 34.3-month median survival with first-line RYBREVANT plus chemotherapy, while extensive treatment crossover complicated the final overall-survival analysis. Representative image.
Features & Analysis

Johnson & Johnson says RYBREVANT delivered the longest reported survival in EGFR exon 20 lung cancer. Why was p=0.307?

Johnson & Johnson’s final PAPILLON analysis found median overall survival of 34.3 months with first-line RYBREVANT plus chemotherapy versus 27.9 months with chemotherapy, but the protocol-specified comparison was not statistically significant. With 76% of eligible chemotherapy patients later receiving amivantamab, the trial has become a case study in how effective crossover can obscure overall-survival differences.

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Targeted lung cancer therapy is becoming increasingly important as Johnson & Johnson expands Rybrevant across EGFR-mutated non-small cell lung cancer treatment. Representative image.
Pharma & Biotech

Johnson & Johnson’s Rybrevant reaches 34.3-month survival in EGFR exon 20 lung cancer, but crossover clouds the headline result

Johnson & Johnson’s Rybrevant combination produced a median overall survival of 34.3 months in first-line EGFR exon 20 insertion-positive lung cancer, although the protocol-specified comparison did not reach statistical significance after extensive crossover from chemotherapy.

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