Can AI and chemistry finally converge to drug transcription factors? The race to target the cell’s command center

Can AI and chemistry finally converge to drug transcription factors? The race to target the cell’s command center

For decades, pharmaceutical pipelines have danced around one of biology’s most powerful but untouchable entities: transcription factors. These master regulators control gene expression and orchestrate cellular behavior, yet their structure and function have kept them out of reach for small molecule therapeutics. Unlike enzymes or receptors, transcription factors operate deep within the cell nucleus, often […]

How the Brii–OpenBench deal could redefine early-stage drug discovery economics

How the Brii–OpenBench deal could redefine early-stage drug discovery economics

Brii Biosciences Limited and OpenBench, Inc. have announced a strategic collaboration to integrate OpenBench’s structure-based artificial intelligence platform into Brii Biosciences’ discovery efforts. The partnership grants Brii Biosciences exclusive rights to novel lead compounds identified through OpenBench’s proprietary screening technology. The agreement includes an option to expand into additional programs, underscoring Brii Biosciences’ push into […]

Inside Insilico Medicine’s CKD push: AI-driven ISM4808 heads to Greater China with TaiGen

Inside Insilico Medicine’s CKD push: AI-driven ISM4808 heads to Greater China with TaiGen

Insilico Medicine has licensed its AI-discovered oral PHD inhibitor ISM4808 to TaiGen Biotechnology for exclusive development and commercialization in the Greater China region, including Mainland China, Hong Kong, Macau, and Taiwan. The deal follows Investigational New Drug clearance in China in 2023 and positions TaiGen to bring the asset into clinical trials targeting anemia associated […]